Immunotherapy

Type I Interferon Drives a Cellular State Inert to TCR‐Stimulation and Could Impede Effective T‐Cell Differentiation in Cancer
Head and neck squamous cell carcinoma (HNSCC) is linked to human papillomavirus (HPV) infection. HPV-positive and HPV-negative HNSCC …
Dillon Corvino, Martin Batstone, Brett G M Hughes, Tim Kempchen, Susanna S Ng, Nazhifah Salim, Franziska Schneppenheim, Denise Rommel, Ananthi Kumar, Sally Pearson, Jason Madore, Lambross T Koufariotis, Lisa Maria Steinheuer, Dilan Pathirana, Kevin Thurley, Michael Hölzel, Nick Borcherding, Matthias Braun, Tobias Bald
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be phenotypically distinct from monocyte-derived …
John Baer, Chong Zuo, Liang-I Kang, Angela Alarcon de la Lastra, Nick Borcherding, Brett Knolhoff, Savannah J Bogner, Yu Zhu, Liping Yang, Jennifer Laurent, Mark Lewis, Nan Zhang, Ki-Wook Kim, Ryan C Fields, Wayne M Yokoyama, Jason C Mills, Li Ding, Gwendalyn J Randolph, David DeNardo
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
Chronic activation of inflammatory pathways and suppressed interferon are hallmarks of immunosuppressive tumors. Previous studies have …
Xiuting Liu, Graham Hogg, Chong Zuo, Nick Borcherding, John Baer, Varintra Lander, Liang-I Kang, Brett Knolhoff, Faiz Ahmad, Robin Osterhout, Anna Galkin, Jean- Marie Bruey, Laura Carter, Cedric Mpoy, Kiran Vij, Ryan Fields, Julie Schwarz, Haeseong Park, Vineet Gupta, David DeNardo
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IL-17 cytokines preferentially act on naïve CD4+ T cells with the IL-17AF heterodimer inducing the greatest functional changes.
CD4+ T-helper 17 (Th17) T cells are a key population in protective immunity during infection and in self-tolerance/autoimmunity. …
Michael P Crawford, Nick Borcherding, Nitin J Karandikar
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune …
Mingyu He, Kate Roussak, Feiyang Ma, Nick Borcherding, Vince Garin, Mike White, Charles Schutt, Trine Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert Modlin, Ryan C. Fields, Robert Schreiber, Paul M. Allen, Eynav Klechevsky
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
Updates on Immunotherapy and Immune Landscape in Renal Clear Cell Carcinoma
Several clinicopathological features of clear cell renal cell carcinomas (ccRCC) contribute to make an “atypical” cancer, …
Myung-Chul Kim, Zeng Jin, Ryan Kolb, Nick Borcherding, Jonathan Alexander Chatzkel, Sara Moscovita Falzarano, Weizhou Zhang
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CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but …
Myung-Chul Kim, Nick Borcherding, Kawther K Ahmed, Andrew P Voigt, Ajaykumar Vishwakarma, Ryan Kolb, Paige N Kluz, Gaurav Pandey, Umasankar De, Theodore Drashansky, Eric Y Helm, Xin Zhang, Katherine N Gibson-Corley, Julia Klesney-Tait, Yuwen Zhu, Jinglu Lu, Jinsong Lu, Xian Huang, Hongrui Xiang, Jinke Cheng, Dongyang Wang, Zheng Wang, Jian Tang, Jiajia Hu, Zhengting Wang, Hua Liu, Mingjia Li, Haoyang Zhuang, Dorina Avram, Daohong Zhou, Rhonda Bacher, Song Guo Zheng, Xuefeng Wu, Yousef Zakharia, Weizhou Zhang
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CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Commentary on a Case of Unexpected Hyperglycemia
Nick Borcherding, Ann M. Gronowski
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The GPR171 pathway suppresses T cell activation and limits antitumor immunity
The recently identified G-protein-coupled receptor GPR171 and its ligand BigLEN are thought to regulate food uptake and anxiety. Though …
Yuki Fujiwara, Robert J Torphy, Yi Sun, Emily N Miller, Felix Ho, Nick Borcherding, Tuoqi Wu, Raul M Torres, Weizhou Zhang, Richard D Schulick, Yuwen Zhu
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Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common …
Ryan Kolb, Umasankar De, Sajid Khan, Yuewan Luo, Myung-Chul Kim, Haijun Yu, Chaoyan Wu, Jiao Mo, Xin Zhang, Peiyi Zhang, Xuan Zhang, Nick Borcherding, Daniel Koppel, Yang-Xin Fu, Song Guo Zheng, Dorina Avram, Guangrong Zheng, Daohong Zhou, Weizhou Zhang
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