Immunotherapy

Multivariable Analysis of 169 Cases of Advanced Cutaneous Melanoma to Evaluate Antibiotic Exposure as Predictor of Survival to Anti-PD-1 Based Immunotherapies
Recently antibiotic exposure has been associated with worse outcomes in patients undergoing treatment with antibodies directed against …
Umang Swami, Adithya Chennamadhavuni, Nick Borcherding, Aaron D Bossler, Sarah L Mott, Rohan Garje, Yousef Zakharia, Mohammed Milhem
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CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression
Untoward effector CD4+ T cell responses are kept in check by immune regulatory mechanisms mediated by CD4+ and CD8+ T cells. CD4+ T …
Michael P Crawford, Sushmita Sinha, Pranav S Renavikar, Nick Borcherding, Nitin J Karandikar
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Therapeutic potential of combining PARP inhibitor and immunotherapy in solid tumors
Immunotherapy has revolutionized the treatment of both hematological malignancies and solid tumors. The use of immunotherapy has …
Praveen Vikas, Nick Borcherding, Adithya Chennamadhavuni, Rohan Garje
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Therapeutic potential of combining PARP inhibitor and immunotherapy in solid tumors
IL-1 Signaling in Tumor Microenvironment
Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation that plays a complex, and sometimes contrasting, …
Weizhou Zhang, Nick Borcherding, Ryan Kolb
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The clinical promise of immunotherapy in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease with poorer outcomes compared to other breast cancer subtypes. …
Praveen Vikas, Nicholas Borcherding, Weizhou Zhang
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Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer
Immune checkpoints are a diverse set of inhibitory signals to the immune system that play a functional role in adaptive immune response …
Nick Borcherding, Ryan Kolb, Jodi Gullicksrud, Praveen Vikas, Yuwen Zhu, Weizhou Zhang
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Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer