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Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren's disease
Childhood Sjögren’s disease represents critically unmet medical needs due to a complete lack of immunological and molecular …
Myung-Chul Kim, Umasankar De, Nick Borcherding, Lei Wang, Joon Paek, Indraneel Bhattacharyya, Qing Yu, Ryan Kolb, Theodore Drashansky, Akaluck Thatayatikom, Weizhou Zhang, Seunghee Cha
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Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune …
Sergio Irac, Megan Sioe Fei Soon, Nick Borcherding, Zewen Kelvin Tuong
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Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is refractory to immune checkpoint inhibitor therapy. However, …
Vikram S Pothuri, Graham D Hogg, Leah Conant, Nicholas Borcherding, C Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G Hawkins, Venu G Pillarisetty, David G DeNardo, Ryan C Fields
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The power and potential of mitochondria transfer
Mitochondria are believed to have originated through an ancient endosymbiotic process in which proteobacteria were captured and …
Nick Borcherding, Jonathan Brestoff
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The power and potential of mitochondria transfer
T Cell Clonal Analysis Using Single-cell RNA Sequencing and Reference Maps
T cells are endowed with T-cell antigen receptors (TCR) that give them the capacity to recognize specific antigens and mount …
Massimo Andreatta, Paul Gueguen, Nick Borcherding, Santiago Carmona
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Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma
Cutaneous T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a …
Mitchell N Lefebvre, Nick Borcherding, Ryan J Reis, Eric Mou, Vincent Liu, Ali Jabbari
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be phenotypically distinct from monocyte-derived …
John Baer, Chong Zuo, Liang-I Kang, Angela Alarcon de la Lastra, Nick Borcherding, Brett Knolhoff, Savannah J Bogner, Yu Zhu, Liping Yang, Jennifer Laurent, Mark Lewis, Nan Zhang, Ki-Wook Kim, Ryan C Fields, Wayne M Yokoyama, Jason C Mills, Li Ding, Gwendalyn J Randolph, David DeNardo
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Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules
Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the …
Lotus Westerhof, Jonathan Noonan, Kerrie Hargrave, Elizabeth Chimbayo, Zhiling Cheng, Varintra Lander, Thomas Purnell, Mark Jackson, Nick Borcherding, Megan MacLeod
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Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer
Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune checkpoint blockade has improved survival for …
Brett H Herzog, John M Baer, Nick Borcherding, Natalie L Kingston, Jad I Belle, Brett L Knolhoff, Graham D Hogg, Faiz Ahmad, Liang-I Kang, Jessica Petrone, Chieh-Yu Lin, Ramaswamy Govindan, David G DeNardo
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
Chronic activation of inflammatory pathways and suppressed interferon are hallmarks of immunosuppressive tumors. Previous studies have …
Xiuting Liu, Graham Hogg, Chong Zuo, Nick Borcherding, John Baer, Varintra Lander, Liang-I Kang, Brett Knolhoff, Faiz Ahmad, Robin Osterhout, Anna Galkin, Jean- Marie Bruey, Laura Carter, Cedric Mpoy, Kiran Vij, Ryan Fields, Julie Schwarz, Haeseong Park, Vineet Gupta, David DeNardo
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