Immune Response

Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune …
Sergio Irac, Megan Sioe Fei Soon, Nick Borcherding, Zewen Kelvin Tuong
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T Cell Clonal Analysis Using Single-cell RNA Sequencing and Reference Maps
T cells are endowed with T-cell antigen receptors (TCR) that give them the capacity to recognize specific antigens and mount …
Massimo Andreatta, Paul Gueguen, Nick Borcherding, Santiago Carmona
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Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules
Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the …
Lotus Westerhof, Jonathan Noonan, Kerrie Hargrave, Elizabeth Chimbayo, Zhiling Cheng, Varintra Lander, Thomas Purnell, Mark Jackson, Nick Borcherding, Megan MacLeod
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Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer
Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune checkpoint blockade has improved survival for …
Brett H Herzog, John M Baer, Nick Borcherding, Natalie L Kingston, Jad I Belle, Brett L Knolhoff, Graham D Hogg, Faiz Ahmad, Liang-I Kang, Jessica Petrone, Chieh-Yu Lin, Ramaswamy Govindan, David G DeNardo
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IL-17 cytokines preferentially act on naïve CD4+ T cells with the IL-17AF heterodimer inducing the greatest functional changes.
CD4+ T-helper 17 (Th17) T cells are a key population in protective immunity during infection and in self-tolerance/autoimmunity. …
Michael P Crawford, Nick Borcherding, Nitin J Karandikar
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IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse
Jehan Alam, Ghasem Yazdanpanah, Rinki Ratnapriya, Nick Borcherding, Cintia S De Paiva, DeQuan Li, Rodrigo Guimaraes de Souza, Zhiyuan Yu, Stephen C Pflugfelder
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Dissecting the cellular landscape and transcriptome network in viral myocarditis by single-cell RNA sequencing
Coxsackievirus B3 (CVB3)-induced myocarditis is commonly employed to study viral pathogenesis in mice. Chronically affected mice may …
Ninaad Lasrado, Nick Borcherding, Rajkumar Arumugam, Timothy K Starr, Jay Reddy
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Comprehensive immunologic evaluation of bronchoalveolar lavage samples from human patients with moderate and severe seasonal influenza and severe COVID-19
Infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or seasonal influenza may lead to respiratory failure …
Daniel Reynolds, Cristina Vazquez Guillamet, Aaron Day, Nick Borcherding, Rodrigo Vazquez Guillamet, José Alberto Choreño-Parra, Stacey L House, Jane A O’Halloran, Joaquín Zúñiga, Ali H Ellebedy, Derek E Byers, Philip A Mudd
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Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells
B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, …
Nimitha R Mathew, Jayalal K Jayanthan, Ilya V Smirnov, Jonathan L Robinson, Hannes Axelsson, Sravya S Nakka, Aikaterini Emmanouilidi, Paulo Czarnewski, William T Yewdell, Karin Schön, Cristina Lebrero-Fernández, Valentina Bernasconi, William Rodin, Ali M Harandi, Nils Lycke, Nick Borcherding, Jonathan W Yewdell, Victor Greiff, Mats Bemark, Davide Angeletti
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SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2
In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast-derived mAbs from individuals who received …
Fatima Amanat, Mahima Thapa, Tinting Lei, Shaza M. Sayed Ahmed, Daniel C. Adelsberg, Juan Manuel Carreño, Shirin Strohmeier, Aaron J. Schmitz, Sarah Zafar, Julian Q. Zhou, Willemijn Rijnink, Hala Alshammary, Nick Borcherding, Ana Gonzalez Reiche, Komal Srivastava, Emilia Mia Sordillo, Harm van Bakel, Jackson S. Turner, Goran Bajic, Viviana Simon, Ali H. Ellebedy, Florian Krammer
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SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2