TCR

Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules
Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the …
Lotus Westerhof, Jonathan Noonan, Kerrie Hargrave, Elizabeth Chimbayo, Zhiling Cheng, Varintra Lander, Thomas Purnell, Mark Jackson, Nick Borcherding, Megan MacLeod
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Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer
Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune checkpoint blockade has improved survival for …
Brett H Herzog, John M Baer, Nick Borcherding, Natalie L Kingston, Jad I Belle, Brett L Knolhoff, Graham D Hogg, Faiz Ahmad, Liang-I Kang, Jessica Petrone, Chieh-Yu Lin, Ramaswamy Govindan, David G DeNardo
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune …
Mingyu He, Kate Roussak, Feiyang Ma, Nick Borcherding, Vince Garin, Mike White, Charles Schutt, Trine Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert Modlin, Ryan C. Fields, Robert Schreiber, Paul M. Allen, Eynav Klechevsky
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
scRepertoire v2
A toolkit for single-cell immune profiling
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scRepertoire v2
Trex
Autoencoder for single-cell TCR
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Trex
Utility
Collection of Tumor-Infiltrating Lymphocyte Single-Cell Experiments with TCRs
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Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment
Cutaneous T cell lymphomas (CTCLs) are a spectrum of diseases with varied clinical courses caused by malignant clonal proliferation of …
Nick Borcherding, Kevin J Severson, Nicholas Henderson, Luana S Ortolan, Allison C Rosenthal, Andrew M Bellizzi, Vincent Liu, Brian K Link, Aaron R Mangold, Ali Jabbari
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Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but …
Myung-Chul Kim, Nick Borcherding, Kawther K Ahmed, Andrew P Voigt, Ajaykumar Vishwakarma, Ryan Kolb, Paige N Kluz, Gaurav Pandey, Umasankar De, Theodore Drashansky, Eric Y Helm, Xin Zhang, Katherine N Gibson-Corley, Julia Klesney-Tait, Yuwen Zhu, Jinglu Lu, Jinsong Lu, Xian Huang, Hongrui Xiang, Jinke Cheng, Dongyang Wang, Zheng Wang, Jian Tang, Jiajia Hu, Zhengting Wang, Hua Liu, Mingjia Li, Haoyang Zhuang, Dorina Avram, Daohong Zhou, Rhonda Bacher, Song Guo Zheng, Xuefeng Wu, Yousef Zakharia, Weizhou Zhang
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CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common …
Ryan Kolb, Umasankar De, Sajid Khan, Yuewan Luo, Myung-Chul Kim, Haijun Yu, Chaoyan Wu, Jiao Mo, Xin Zhang, Peiyi Zhang, Xuan Zhang, Nick Borcherding, Daniel Koppel, Yang-Xin Fu, Song Guo Zheng, Dorina Avram, Guangrong Zheng, Daohong Zhou, Weizhou Zhang
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Mapping the immune environment in clear cell renal carcinoma by single-cell genomics
Clear cell renal cell carcinoma (ccRCC) is one of the most immunologically distinct tumor types due to high response rate to …
Nick Borcherding, Ajaykumar Vishwakarma, Andrew P. Voigt, Andrew Bellizzi, Jacob Kaplan, Kenneth Nepple, Aliasger K Salem, Russell W Jenkins, Yousef Zakharia, Weizhou Zhang
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Mapping the immune environment in clear cell renal carcinoma by single-cell genomics