TCR

Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren's disease
Childhood Sjögren’s disease represents critically unmet medical needs due to a complete lack of immunological and molecular …
Myung-Chul Kim, Umasankar De, Nick Borcherding, Lei Wang, Joon Paek, Indraneel Bhattacharyya, Qing Yu, Ryan Kolb, Theodore Drashansky, Akaluck Thatayatikom, Weizhou Zhang, Seunghee Cha
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Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune …
Sergio Irac, Megan Sioe Fei Soon, Nick Borcherding, Zewen Kelvin Tuong
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Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is refractory to immune checkpoint inhibitor therapy. However, …
Vikram S Pothuri, Graham D Hogg, Leah Conant, Nicholas Borcherding, C Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G Hawkins, Venu G Pillarisetty, David G DeNardo, Ryan C Fields
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T Cell Clonal Analysis Using Single-cell RNA Sequencing and Reference Maps
T cells are endowed with T-cell antigen receptors (TCR) that give them the capacity to recognize specific antigens and mount …
Massimo Andreatta, Paul Gueguen, Nick Borcherding, Santiago Carmona
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Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma
Cutaneous T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a …
Mitchell N Lefebvre, Nick Borcherding, Ryan J Reis, Eric Mou, Vincent Liu, Ali Jabbari
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Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules
Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the …
Lotus Westerhof, Jonathan Noonan, Kerrie Hargrave, Elizabeth Chimbayo, Zhiling Cheng, Varintra Lander, Thomas Purnell, Mark Jackson, Nick Borcherding, Megan MacLeod
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Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer
Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune checkpoint blockade has improved survival for …
Brett H Herzog, John M Baer, Nick Borcherding, Natalie L Kingston, Jad I Belle, Brett L Knolhoff, Graham D Hogg, Faiz Ahmad, Liang-I Kang, Jessica Petrone, Chieh-Yu Lin, Ramaswamy Govindan, David G DeNardo
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune …
Mingyu He, Kate Roussak, Feiyang Ma, Nick Borcherding, Vince Garin, Mike White, Charles Schutt, Trine Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert Modlin, Ryan C. Fields, Robert Schreiber, Paul M. Allen, Eynav Klechevsky
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
scRepertoire v2
A toolkit for single-cell immune profiling
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scRepertoire v2
Trex
Autoencoder for single-cell TCR
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Trex