Single-Cell

CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but …
Single-cell BCR and transcriptome analysis after influenza infection reveals spatiotemporal dynamics of antigen-specific B cells
B cell responses are critical for antiviral immunity. However, a comprehensive picture of antigen-specific B cell differentiation, …
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2
In this study we profiled vaccine-induced polyclonal antibodies as well as plasmablast-derived mAbs from individuals who received …
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells
Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common …
AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells
Mammary gland ductal morphogenesis depends on the differentiation of mammary stem cells (MaSCs) into basal and luminal lineages. The …