Single-Cell

Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren's disease
Childhood Sjögren’s disease represents critically unmet medical needs due to a complete lack of immunological and molecular …
Myung-Chul Kim, Umasankar De, Nick Borcherding, Lei Wang, Joon Paek, Indraneel Bhattacharyya, Qing Yu, Ryan Kolb, Theodore Drashansky, Akaluck Thatayatikom, Weizhou Zhang, Seunghee Cha
PDF Cite DOI Pubmed
Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune …
Sergio Irac, Megan Sioe Fei Soon, Nick Borcherding, Zewen Kelvin Tuong
PDF Cite DOI Pubmed
T Cell Clonal Analysis Using Single-cell RNA Sequencing and Reference Maps
T cells are endowed with T-cell antigen receptors (TCR) that give them the capacity to recognize specific antigens and mount …
Massimo Andreatta, Paul Gueguen, Nick Borcherding, Santiago Carmona
PDF Cite DOI Pubmed
Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma
Cutaneous T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a …
Mitchell N Lefebvre, Nick Borcherding, Ryan J Reis, Eric Mou, Vincent Liu, Ali Jabbari
PDF Cite DOI Pubmed
Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer
Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune checkpoint blockade has improved survival for …
Brett H Herzog, John M Baer, Nick Borcherding, Natalie L Kingston, Jad I Belle, Brett L Knolhoff, Graham D Hogg, Faiz Ahmad, Liang-I Kang, Jessica Petrone, Chieh-Yu Lin, Ramaswamy Govindan, David G DeNardo
PDF Cite DOI Pubmed
CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune …
Mingyu He, Kate Roussak, Feiyang Ma, Nick Borcherding, Vince Garin, Mike White, Charles Schutt, Trine Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert Modlin, Ryan C. Fields, Robert Schreiber, Paul M. Allen, Eynav Klechevsky
PDF Cite Code DOI Pubmed
CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
scRepertoire v2
A toolkit for single-cell immune profiling
Code Follow
scRepertoire v2
Utility
Collection of Tumor-Infiltrating Lymphocyte Single-Cell Experiments with TCRs
Code Follow
Stromal reprogramming by FAK inhibition overcomes radiation resistance to allow for immune priming and response to checkpoint blockade
The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma (PDAC) are not well understood. To better …
Varintra E Lander, Jad I Belle, Natalie L Kingston, John M Herndon, Graham D Hogg, Xiuting Liu, Liang-I Kang, Brett L Knolhoff, Savannah J Bogner, John M Baer, Chong Zuo, Nick Borcherding, Daniel P Lander, Cedric Mpoy, Jalen Scott, Michael Zahner, Buck E Rogers, Julie K Schwarz, Hyun Kim, David G DeNardo
PDF Cite DOI Pubmed
Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment
Cutaneous T cell lymphomas (CTCLs) are a spectrum of diseases with varied clinical courses caused by malignant clonal proliferation of …
Nick Borcherding, Kevin J Severson, Nicholas Henderson, Luana S Ortolan, Allison C Rosenthal, Andrew M Bellizzi, Vincent Liu, Brian K Link, Aaron R Mangold, Ali Jabbari
PDF Cite DOI Pubmed
Single-cell analysis of Sézary syndrome reveals novel markers and shifting gene profiles associated with treatment