Single-Cell

Leveraging single-cell transcriptomic data to uncover immune suppressive cancer cell subsets in triple-negative canine breast cancers
Single-cell RNA sequencing (scRNA-seq) has become an essential tool for uncovering the complexities of various physiological and …
Myung-Chul Kim, Myung-Chul Kim, Nick Borcherding, Woo-Jin Song,, Ryan Kolb, Weizhou Zhang
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CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA vaccination induce robust CD4+ T cell responses. Using …
Nick Borcherding, Wooseob Kim, Michael Quinn, Fangjie Han, Julian Q Zhou, Alexandria J Sturtz, Aaron J Schmitz, Tingting Lei, Stefan A Schattgen, Michael K Klebert, Teresa Suessen, William D Middleton, Charles W Goss, Chang Liu, Jeremy Chase Crawford, Paul G Thomas, Sharlene A Teefey, Rachel M Presti, Jane A O'Halloran, Jackson S Turner, Ali H Ellebedy, Philip A Mudd
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CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans
Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren's disease
Childhood Sjögren’s disease represents critically unmet medical needs due to a complete lack of immunological and molecular …
Myung-Chul Kim, Umasankar De, Nick Borcherding, Lei Wang, Joon Paek, Indraneel Bhattacharyya, Qing Yu, Ryan Kolb, Theodore Drashansky, Akaluck Thatayatikom, Weizhou Zhang, Seunghee Cha
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Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune …
Sergio Irac, Megan Sioe Fei Soon, Nick Borcherding, Zewen Kelvin Tuong
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Type I Interferon Drives a Cellular State Inert to TCR‐Stimulation and Could Impede Effective T‐Cell Differentiation in Cancer
Head and neck squamous cell carcinoma (HNSCC) is linked to human papillomavirus (HPV) infection. HPV-positive and HPV-negative HNSCC …
Dillon Corvino, Martin Batstone, Brett G M Hughes, Tim Kempchen, Susanna S Ng, Nazhifah Salim, Franziska Schneppenheim, Denise Rommel, Ananthi Kumar, Sally Pearson, Jason Madore, Lambross T Koufariotis, Lisa Maria Steinheuer, Dilan Pathirana, Kevin Thurley, Michael Hölzel, Nick Borcherding, Matthias Braun, Tobias Bald
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T Cell Clonal Analysis Using Single-cell RNA Sequencing and Reference Maps
T cells are endowed with T-cell antigen receptors (TCR) that give them the capacity to recognize specific antigens and mount …
Massimo Andreatta, Paul Gueguen, Nick Borcherding, Santiago Carmona
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Molecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma
Cutaneous T cell lymphoma (CTCL), characterized by malignant T cells infiltrating the skin with potential for dissemination, remains a …
Mitchell N Lefebvre, Nick Borcherding, Ryan J Reis, Eric Mou, Vincent Liu, Ali Jabbari
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Tumor-associated fibrosis impairs immune surveillance and response to immune checkpoint blockade in non-small cell lung cancer
Non–small cell lung cancer (NSCLC) is a leading cause of cancer-related deaths. Immune checkpoint blockade has improved survival for …
Brett H Herzog, John M Baer, Nick Borcherding, Natalie L Kingston, Jad I Belle, Brett L Knolhoff, Graham D Hogg, Faiz Ahmad, Liang-I Kang, Jessica Petrone, Chieh-Yu Lin, Ramaswamy Govindan, David G DeNardo
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune …
Mingyu He, Kate Roussak, Feiyang Ma, Nick Borcherding, Vince Garin, Mike White, Charles Schutt, Trine Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert Modlin, Ryan C. Fields, Robert Schreiber, Paul M. Allen, Eynav Klechevsky
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
scRepertoire v2
A toolkit for single-cell immune profiling
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scRepertoire v2