Obesity

Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood
Adipocytes transfer mitochondria to macrophages in white and brown adipose tissues to maintain metabolic homeostasis. In obesity, …
Nick Borcherding, Wentong Jia, Rocky Giwa, Rachael L Field, John R Moley, Benjamin J Kopecky, Mandy M Chan, Bin Q Yang, Jessica M Sabio, Emma C Walker, Omar Osorio, Andrea L Bredemeyer, Terri Pietka, Jennifer Alexander-Brett, Sharon Celeste Morley, Maxim N Artyomov, Nada A Abumrad, Joel Schilling, Kory Lavine, Clair Crewe, Jonathan R Brestoff
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Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood
Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue
Recent findings have demonstrated that mitochondria can be transferred between cells to control metabolic homeostasis. Although the …
Marco Rosina, Veronica Ceci, Riccardo Turchi, Li Chuan, Nick Borcherding, Francesca Sciarretta, María Sánchez-Díaz, Flavia Tortolici, Keaton Karlinsey, Valerio Chiurchiù, Claudia Fuoco, Rocky Giwa, Rachael L Field, Matteo Audano, Simona Arena, Alessandro Palma, Federica Riccio, Farnaz Shamsi, Giovanni Renzone, Martina Verri, Anna Crescenzi, Salvatore Rizza, Fiorella Faienza, Giuseppe Filomeni, Sander Kooijman, Stefano Rufini, Antoine AF de Vries, Andrea Scaloni, Nico Mitro, Yu-Hua Tseng, Andrés Hidalgo, Beiyan Zhou, Jonathan R Brestoff, Katia Aquilano, Daniele Lettieri-Barbato
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Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to …
Ryan Kolb, Paige Kluz, Zhen Wei Tan, Nick Borcherding, Nicholas Bormann, Ajaykumar Vishwakarma, Louis Balcziak, Pengcheng Zhu, Brandon Sj Davies, Francoise Gourronc, Ling-Zhi Liu, Xin Ge, Bing-Hua Jiang, Katherine Gibson-Corley, Aloysius Klingelhutz, Nguan Soon Tan, Yuwen Zhu, Fayyaz S Sutterwala, Xian Shen, Weizhou Zhang
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Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
Obesity is associated with an increased risk of developing breast cancer and is also associated with worse clinical prognosis. The …
Ryan Kolb, Liem Phan, Nick Borcherding, Yinghong Liu, Fang Yuan, Ann M Janowski, Qing Xie, Kathleen R Markan, Wei Li, Matthew J Potthoff, Enrique Fuentes-Mattei, Lesley G Ellies, C Michael Knudson, Mong-Hong Lee, Sai-Ching J Yeung, Suzanne L Cassel, Fayyaz S Sutterwala, Weizhou Zhang
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Dietary resistant starch prevents urinary excretion of 25-hydroxycholecalciferol and vitamin D-binding protein in type 1 diabetic rats
Diabetes is a rapidly growing epidemic affecting millions of Americans and has been implicated in a number of devastating secondary …
Anne L Smazal, Nick Borcherding, Alysse S Anderegg,, Kevin L Schalinske, Elizabeth M Whitley, Matthew J Rowling
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