inflammation

Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism
Rachel L Shrode, Nicole Cady, Samantha N Jensen, Nick Borcherding, Ashutosh K Mangalam
PDF DOI Pubmed
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to …
Ryan Kolb, Paige Kluz, Zhen Wei Tan, Nick Borcherding, Nicholas Bormann, Ajaykumar Vishwakarma, Louis Balcziak, Pengcheng Zhu, Brandon Sj Davies, Francoise Gourronc, Ling-Zhi Liu, Xin Ge, Bing-Hua Jiang, Katherine Gibson-Corley, Aloysius Klingelhutz, Nguan Soon Tan, Yuwen Zhu, Fayyaz S Sutterwala, Xian Shen, Weizhou Zhang
PDF DOI Pubmed
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
Obesity is associated with an increased risk of developing breast cancer and is also associated with worse clinical prognosis. The …
Ryan Kolb, Liem Phan, Nick Borcherding, Yinghong Liu, Fang Yuan, Ann M Janowski, Qing Xie, Kathleen R Markan, Wei Li, Matthew J Potthoff, Enrique Fuentes-Mattei, Lesley G Ellies, C Michael Knudson, Mong-Hong Lee, Sai-Ching J Yeung, Suzanne L Cassel, Fayyaz S Sutterwala, Weizhou Zhang
PDF DOI Pubmed
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of …
Xuefeng Wu, Weizhou Zhang, Joan Font-Burgada, Trenis Palmer, Alexander S Hamil, Subhra K Biswas, Michael Poidinger, Nick Borcherding, Qing Xie, Lesley G Ellies, Nikki K Lytle, Li-Wha Wu, Raymond G Fox, Jing Yang, Steven F Dowdy, Tannishtha Reya, Michael Karin
PDF DOI Pubmed
A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1
IκB kinase α (IKKα) activity is required for ErbB2-induced mammary tumorigenesis. Here, we show that IKKα and its activator, …
Weizhou Zhang, Wei Tan, Xuefeng Wu, Maxim Poustovoitov, Amy Strasner, Wei Li, Nicholas Borcherding, Majid Ghassemian, Michael Karin
PDF DOI Pubmed