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Immunotherapy
The anti-tumor effects of cetuximab in combination with VTX-2337 are T cell dependent
The Toll-like receptor 8 (TLR8) agonist VTX-2337 (motolimod) is an anti-cancer immunotherapeutic agent that is believed to augment …
Yinwen Cheng
,
Nick Borcherding
,
Ayomide Ogunsakin
,
Caitlin D Lemke-Miltner
,
Katherine N Gibson-Corley
,
Anand Rajan
,
Allen B Choi
,
Wattawan Wongpattaraworakul
,
Carlos H F Chan
,
Aliasger K Salem
,
George J Weiner
,
Andrean L Simons
PDF
DOI
Pubmed
Multivariable Analysis of 169 Cases of Advanced Cutaneous Melanoma to Evaluate Antibiotic Exposure as Predictor of Survival to Anti-PD-1 Based Immunotherapies
Recently antibiotic exposure has been associated with worse outcomes in patients undergoing treatment with antibodies directed against …
Umang Swami
,
Adithya Chennamadhavuni
,
Nick Borcherding
,
Aaron D Bossler
,
Sarah L Mott
,
Rohan Garje
,
Yousef Zakharia
,
Mohammed Milhem
PDF
DOI
Pubmed
CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression
Untoward effector CD4+ T cell responses are kept in check by immune regulatory mechanisms mediated by CD4+ and CD8+ T cells. CD4+ T …
Michael P Crawford
,
Sushmita Sinha
,
Pranav S Renavikar
,
Nick Borcherding
,
Nitin J Karandikar
PDF
DOI
Pubmed
Therapeutic potential of combining PARP inhibitor and immunotherapy in solid tumors
Immunotherapy has revolutionized the treatment of both hematological malignancies and solid tumors. The use of immunotherapy has …
Praveen Vikas
,
Nick Borcherding
,
Adithya Chennamadhavuni
,
Rohan Garje
PDF
DOI
Pubmed
IL-1 Signaling in Tumor Microenvironment
Interleukin 1 (IL-1) has long been known for its pleiotropic effects on inflammation that plays a complex, and sometimes contrasting, …
Weizhou Zhang
,
Nick Borcherding
,
Ryan Kolb
PDF
DOI
Pubmed
The clinical promise of immunotherapy in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease with poorer outcomes compared to other breast cancer subtypes. …
Praveen Vikas
,
Nicholas Borcherding
,
Weizhou Zhang
PDF
DOI
Pubmed
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer
Immune checkpoints are a diverse set of inhibitory signals to the immune system that play a functional role in adaptive immune response …
Nick Borcherding
,
Ryan Kolb
,
Jodi Gullicksrud
,
Praveen Vikas
,
Yuwen Zhu
,
Weizhou Zhang
PDF
DOI
Pubmed
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