Immunology

Leveraging single-cell transcriptomic data to uncover immune suppressive cancer cell subsets in triple-negative canine breast cancers
Single-cell RNA sequencing (scRNA-seq) has become an essential tool for uncovering the complexities of various physiological and …
Myung-Chul Kim, Myung-Chul Kim, Nick Borcherding, Woo-Jin Song,, Ryan Kolb, Weizhou Zhang
PDF DOI Pubmed
CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA vaccination induce robust CD4+ T cell responses. Using …
Nick Borcherding, Wooseob Kim, Michael Quinn, Fangjie Han, Julian Q Zhou, Alexandria J Sturtz, Aaron J Schmitz, Tingting Lei, Stefan A Schattgen, Michael K Klebert, Teresa Suessen, William D Middleton, Charles W Goss, Chang Liu, Jeremy Chase Crawford, Paul G Thomas, Sharlene A Teefey, Rachel M Presti, Jane A O'Halloran, Jackson S Turner, Ali H Ellebedy, Philip A Mudd
PDF Code DOI Pubmed
CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans
Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules
Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the …
Lotus Westerhof, Jonathan Noonan, Kerrie Hargrave, Elizabeth Chimbayo, Zhiling Cheng, Varintra Lander, Thomas Purnell, Mark Jackson, Nick Borcherding, Megan MacLeod
PDF DOI Pubmed
Ibex
Autoencoder for single-cell BCR
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Ibex
scRepertoire v2
A toolkit for single-cell immune profiling
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scRepertoire v2
Trex
Autoencoder for single-cell TCR
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Trex
Utility
Collection of Tumor-Infiltrating Lymphocyte Single-Cell Experiments with TCRs
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