Immune Response

Big Data Analytics and Cancer Biology: Lessons in Taking Science from the Processor to the Patient
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An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPγ and heightened effector state in human CD8 T-cells
Multiple GWAS studies have shown that the SNP rs2281808 TT variant, present within the SIRPG gene, is associated with autoimmune …
Sushmita Sinha, Nick Borcherding, Pranav S Renavikar, Michael P Crawford, Eva Tsalikian,, Michael Tansey, Ezzatollah T Shivapour, Frank Bittner, John Kamholz, Heena Olalde, Emilee Gibson, Nitin J Karandikar
PDF DOI Pubmed
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer
Immune checkpoints are a diverse set of inhibitory signals to the immune system that play a functional role in adaptive immune response …
Nick Borcherding, Ryan Kolb, Jodi Gullicksrud, Praveen Vikas, Yuwen Zhu, Weizhou Zhang
PDF DOI Pubmed
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer
Bone marrow stromal antigen 2 (BST-2) DNA is demethylated in breast tumors and breast cancer cells
Wadie D Mahauad-Fernandez, Nick Borcherding, Weizhou Zhang, Chioma M Okeoma
PDF DOI Pubmed
Characterization of a novel mouse model with genetic deletion of CD177
Neutrophils play an essential role in the innate immune response to infection. Neutrophils migrate from the vasculature into the tissue …
Qing Xie, Julia Klesney-Tait, Kathy Keck, Corey Parlet, Nick Borcherding, Ryan Kolb, Wei Li, Lorraine Tygrett, Thomas Waldschmidt, Alicia Olivier, Songhai Chen, Guang-Hui Liu, Xiangrui Li, Weizhou Zhang
PDF DOI Pubmed