cancer

Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer
E-cadherin is conventionally considered to be a good prognostic marker in cancer. The loss of E-cadherin is one of the key hallmarks of …
Nick Borcherding, Kimberly Cole, Paige Kluz, Michael Jorgensen, Ryan Kolb, Andrew Bellizzi, Weizhou Zhang
PDF DOI Pubmed
Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer
Immune checkpoints are a diverse set of inhibitory signals to the immune system that play a functional role in adaptive immune response …
Nick Borcherding, Ryan Kolb, Jodi Gullicksrud, Praveen Vikas, Yuwen Zhu, Weizhou Zhang
PDF DOI Pubmed
Keeping Tumors in Check: A Mechanistic Review of Clinical Response and Resistance to Immune Checkpoint Blockade in Cancer
A novel HER2 gene body enhancer contributes to HER2 expression
The transcriptional regulation of the human epidermal growth factor receptor-2 (HER2) contributes to an enhanced HER2 expression in …
Qi Liu, Mikhail V Kulak, Nick Borcherding, Peterson Maina, Weizhou Zhang, Ronald J Weigel, Hank H Qi
PDF DOI Pubmed
Stabilization of NF-κB-Inducing Kinase Suppresses MLL-AF9-Induced Acute Myeloid Leukemia
Canonical NF-κB signaling is constitutively activated in acute myeloid leukemia (AML) stem cells and is required for maintenance of the …
Yan Xiu, Qianze Dong, Qingchang Li, Fengyin Li, Nick Borcherding, Weizhou Zhang, Brendan Boyce, Hai-hui Xue, Chen Zhao
PDF DOI Pubmed
Obesity-associated NLRC4 inflammasome activation drives breast cancer progression
Obesity is associated with an increased risk of developing breast cancer and is also associated with worse clinical prognosis. The …
Ryan Kolb, Liem Phan, Nick Borcherding, Yinghong Liu, Fang Yuan, Ann M Janowski, Qing Xie, Kathleen R Markan, Wei Li, Matthew J Potthoff, Enrique Fuentes-Mattei, Lesley G Ellies, C Michael Knudson, Mong-Hong Lee, Sai-Ching J Yeung, Suzanne L Cassel, Fayyaz S Sutterwala, Weizhou Zhang
PDF DOI Pubmed
TRGAted: A web tool for survival analysis using protein data in the Cancer Genome Atlas
Reverse-phase protein arrays (RPPAs) are a highthroughput approach to protein quantification utilizing an antibody-based micro-to-nano …
Nick Borcherding, Nicholas Bormann, Andrew P. Voigt, Weizhou Zhang
PDF Code DOI Pubmed
TRGAted: A web tool for survival analysis using protein data in the Cancer Genome Atlas
Paracrine WNT5A signaling in healthy and neoplastic mammary tissue
Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt …
David Kusner, Nick Borcherding, Weizhou Zhang
PDF DOI Pubmed
Transcriptome analysis of basal and luminal tumor-initiating cells in ErbB2-driven breast cancer
Breast cancer is the leading cause of cancer-related mortality for females worldwide. Improving early screening strategies and …
Nick Borcherding, Nicholas Bormann, David Kusner, Ryan Kolb, Weizhou Zhang
PDF DOI Pubmed
Paracrine WNT5A Signaling Inhibits Expansion of Tumor-Initiating Cells
It is not well understood how paracrine communication between basal and luminal cell populations in the mammary gland affects …
Nick Borcherding, David Kusner, Guang-Hui Liu, Weizhou Zhang
PDF DOI Pubmed
Bone marrow stromal antigen 2 (BST-2) DNA is demethylated in breast tumors and breast cancer cells
Wadie D Mahauad-Fernandez, Nick Borcherding, Weizhou Zhang, Chioma M Okeoma
PDF DOI Pubmed