cancer

Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is refractory to immune checkpoint inhibitor therapy. However, …
Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be phenotypically distinct from monocyte-derived …
Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
Chronic activation of inflammatory pathways and suppressed interferon are hallmarks of immunosuppressive tumors. Previous studies have …
CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune …
Stromal reprogramming by FAK inhibition overcomes radiation resistance to allow for immune priming and response to checkpoint blockade
The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma (PDAC) are not well understood. To better …
HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia
Acute myeloid leukemia (AML) is maintained by self-renewing leukemic stem cells (LSCs). A fundamental problem in treating AML is that …
CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but …