cancer

Intratumoral T-cell receptor repertoire composition predicts overall survival in patients with pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is refractory to immune checkpoint inhibitor therapy. However, …
Vikram S Pothuri, Graham D Hogg, Leah Conant, Nicholas Borcherding, C Alston James, Jacqueline Mudd, Greg Williams, Yongwoo David Seo, William G Hawkins, Venu G Pillarisetty, David G DeNardo, Ryan C Fields
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
Tissue-resident macrophages (TRMs) are long-lived cells that maintain locally and can be phenotypically distinct from monocyte-derived …
John Baer, Chong Zuo, Liang-I Kang, Angela Alarcon de la Lastra, Nick Borcherding, Brett Knolhoff, Savannah J Bogner, Yu Zhu, Liping Yang, Jennifer Laurent, Mark Lewis, Nan Zhang, Ki-Wook Kim, Ryan C Fields, Wayne M Yokoyama, Jason C Mills, Li Ding, Gwendalyn J Randolph, David DeNardo
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
Chronic activation of inflammatory pathways and suppressed interferon are hallmarks of immunosuppressive tumors. Previous studies have …
Xiuting Liu, Graham Hogg, Chong Zuo, Nick Borcherding, John Baer, Varintra Lander, Liang-I Kang, Brett Knolhoff, Faiz Ahmad, Robin Osterhout, Anna Galkin, Jean- Marie Bruey, Laura Carter, Cedric Mpoy, Kiran Vij, Ryan Fields, Julie Schwarz, Haeseong Park, Vineet Gupta, David DeNardo
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune …
Mingyu He, Kate Roussak, Feiyang Ma, Nick Borcherding, Vince Garin, Mike White, Charles Schutt, Trine Jensen, Yun Zhao, Courtney A. Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert Modlin, Ryan C. Fields, Robert Schreiber, Paul M. Allen, Eynav Klechevsky
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses
Stromal reprogramming by FAK inhibition overcomes radiation resistance to allow for immune priming and response to checkpoint blockade
The effects of radiotherapy (RT) on tumor immunity in pancreatic ductal adenocarcinoma (PDAC) are not well understood. To better …
Varintra E Lander, Jad I Belle, Natalie L Kingston, John M Herndon, Graham D Hogg, Xiuting Liu, Liang-I Kang, Brett L Knolhoff, Savannah J Bogner, John M Baer, Chong Zuo, Nick Borcherding, Daniel P Lander, Cedric Mpoy, Jalen Scott, Michael Zahner, Buck E Rogers, Julie K Schwarz, Hyun Kim, David G DeNardo
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HSF1 is a driver of leukemia stem cell self-renewal in acute myeloid leukemia
Acute myeloid leukemia (AML) is maintained by self-renewing leukemic stem cells (LSCs). A fundamental problem in treating AML is that …
Qianze Dong, Yan Xiu, Yang Wang, Christina Hodgson, Nick Borcherding, Craig Jordan, Jane Buchanan, Eric Taylor, Brett Wagner, Mariah Leidinger, Carol Holman, Dennis J Thiele, Sean O’Brien, Hai-hui Xue, Jinming Zhao, Qingchang Li, Howard Meyerson, Brendan F Boyce, Chen Zhao
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Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer
The oncogenic role of estrogen receptor (ER) signaling in breast cancer has long been established. Interaction of estrogen with …
Chandra K Maharjan, Jiao Mo, Lei Wang, Myung-Chul Kim, Sameul Wang, Nick Borcherding, Praveen Vikas, Weizhou Zhang
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TIFAB accelerates MLL-AF9− Induced acute myeloid leukemia through upregulation of HOXA9
We previously showed stabilization of NIK-induced activation of NF-κB non-canonical signaling suppresses MLL-AF9-induced AML. In the …
Jinming Zhao, Yan Xiu, Lin Fu, Qianze Dong, Nick Borcherding, Yang Wang, Qingchang Li, Nilushi S De Silva, Ulf Klein, Brendan F Boyce, Chen Zhao
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Updates on Immunotherapy and Immune Landscape in Renal Clear Cell Carcinoma
Several clinicopathological features of clear cell renal cell carcinomas (ccRCC) contribute to make an “atypical” cancer, …
Myung-Chul Kim, Zeng Jin, Ryan Kolb, Nick Borcherding, Jonathan Alexander Chatzkel, Sara Moscovita Falzarano, Weizhou Zhang
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CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells
Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but …
Myung-Chul Kim, Nick Borcherding, Kawther K Ahmed, Andrew P Voigt, Ajaykumar Vishwakarma, Ryan Kolb, Paige N Kluz, Gaurav Pandey, Umasankar De, Theodore Drashansky, Eric Y Helm, Xin Zhang, Katherine N Gibson-Corley, Julia Klesney-Tait, Yuwen Zhu, Jinglu Lu, Jinsong Lu, Xian Huang, Hongrui Xiang, Jinke Cheng, Dongyang Wang, Zheng Wang, Jian Tang, Jiajia Hu, Zhengting Wang, Hua Liu, Mingjia Li, Haoyang Zhuang, Dorina Avram, Daohong Zhou, Rhonda Bacher, Song Guo Zheng, Xuefeng Wu, Yousef Zakharia, Weizhou Zhang
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CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells