breast cancer

Transcriptome analysis of basal and luminal tumor-initiating cells in ErbB2-driven breast cancer
Breast cancer is the leading cause of cancer-related mortality for females worldwide. Improving early screening strategies and …
Nick Borcherding, Nicholas Bormann, David Kusner, Ryan Kolb, Weizhou Zhang
PDF DOI Pubmed
Bone marrow stromal antigen 2 (BST-2) DNA is demethylated in breast tumors and breast cancer cells
Wadie D Mahauad-Fernandez, Nick Borcherding, Weizhou Zhang, Chioma M Okeoma
PDF DOI Pubmed
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade
Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of …
Xuefeng Wu, Weizhou Zhang, Joan Font-Burgada, Trenis Palmer, Alexander S Hamil, Subhra K Biswas, Michael Poidinger, Nick Borcherding, Qing Xie, Lesley G Ellies, Nikki K Lytle, Li-Wha Wu, Raymond G Fox, Jing Yang, Steven F Dowdy, Tannishtha Reya, Michael Karin
PDF DOI Pubmed
Noncanonical Wnt signaling in breast cancer initiation and progression
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A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1
IκB kinase α (IKKα) activity is required for ErbB2-induced mammary tumorigenesis. Here, we show that IKKα and its activator, …
Weizhou Zhang, Wei Tan, Xuefeng Wu, Maxim Poustovoitov, Amy Strasner, Wei Li, Nicholas Borcherding, Majid Ghassemian, Michael Karin
PDF DOI Pubmed