breast cancer

Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer
The oncogenic role of estrogen receptor (ER) signaling in breast cancer has long been established. Interaction of estrogen with …
Chandra K Maharjan, Jiao Mo, Lei Wang, Myung-Chul Kim, Sameul Wang, Nick Borcherding, Praveen Vikas, Weizhou Zhang
PDF DOI Pubmed
AP-2γ Is Required for Maintenance of Multipotent Mammary Stem Cells
Mammary gland ductal morphogenesis depends on the differentiation of mammary stem cells (MaSCs) into basal and luminal lineages. The …
Vivian W Gu, Edward Cho, Dakota T Thompson, Victoria C Cassady, Nick Borcherding, Kelsey E Koch, Vincent T Wu, Allison W Lorenzen, Dana M van der Heide, Jeffrey R White, Mikhail V Kulak, Trevor Williams, Weizhou Zhang, Ronald J Weigel
PDF DOI Pubmed
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling
Aiming to identify immune molecules with a novel function in cancer pathogenesis, we found the cluster of differentiation 177 (CD177), …
Paige N Kluz, Ryan Kolb, Qing Xie, Nick Borcherding, Qi Liu, Yuewan Luo, Myung-Chul Kim, Linna Wang, Yinan Zhang, Wei Li, Christopher Stipp, Katherine N Gibson-Corley, Chen Zhao, Hank H Qi, Andrew Bellizzi, Andy W Tao, Sonia Sugg, Ronald J Weigel, Daohong Zhou, Xian Shen, Weizhou Zhang
PDF DOI Pubmed
Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
Qi Liu, Nick Borcherding, Peng Shao, Peterson K Maina, Weizhou Zhang, Hank H Qi
PDF DOI Pubmed
A TFAP2C Gene Signature Is Predictive of Outcome in HER2-Positive Breast Cancer
The AP-2γ transcription factor, encoded by the TFAP2C gene, regulates the expression of estrogen receptor-alpha (ERα) and other genes …
Vincent T Wu, Boris Kiriazov, Kelsey E Koch, Vivian W Gu, Anna C Beck, Nick Borcherding, Tiandao Li, Peter Addo, Zachary J Wehrspan, Weizhou Zhang, Terry A Braun, Bartley J Brown, Vimla Band, Hamid Band, Mikhail V Kulak, Ronald J Weigel
PDF DOI Pubmed
ROR1 Potentiates FGFR Signaling in Basal-Like Breast Cancer
Among all breast cancer types, basal-like breast cancer (BLBC) represents an aggressive subtype that lacks targeted therapy. We and …
Gaurav Pandey, Nick Borcherding, Ryan Kolb, Paige Kluz, Wei Li, Sonia Sugg, Jun Zhang, Dazhi A Lai, Weizhou Zhang
PDF DOI Pubmed
Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Obesity is a risk factor for breast cancer and also predicts poor clinical outcomes regardless of menopausal status. Contributing to …
Ryan Kolb, Paige Kluz, Zhen Wei Tan, Nick Borcherding, Nicholas Bormann, Ajaykumar Vishwakarma, Louis Balcziak, Pengcheng Zhu, Brandon Sj Davies, Francoise Gourronc, Ling-Zhi Liu, Xin Ge, Bing-Hua Jiang, Katherine Gibson-Corley, Aloysius Klingelhutz, Nguan Soon Tan, Yuwen Zhu, Fayyaz S Sutterwala, Xian Shen, Weizhou Zhang
PDF DOI Pubmed
The clinical promise of immunotherapy in triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous disease with poorer outcomes compared to other breast cancer subtypes. …
Praveen Vikas, Nicholas Borcherding, Weizhou Zhang
PDF DOI Pubmed
Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer
E-cadherin is conventionally considered to be a good prognostic marker in cancer. The loss of E-cadherin is one of the key hallmarks of …
Nick Borcherding, Kimberly Cole, Paige Kluz, Michael Jorgensen, Ryan Kolb, Andrew Bellizzi, Weizhou Zhang
PDF DOI Pubmed
Re-Evaluating E-Cadherin and β-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer
A novel HER2 gene body enhancer contributes to HER2 expression
The transcriptional regulation of the human epidermal growth factor receptor-2 (HER2) contributes to an enhanced HER2 expression in …
Qi Liu, Mikhail V Kulak, Nick Borcherding, Peterson Maina, Weizhou Zhang, Ronald J Weigel, Hank H Qi
PDF DOI Pubmed