Autoimmune

Isoflavone consumption reduces inflammation through modulation of phenylalanine and lipid metabolism
Rachel L Shrode, Nicole Cady, Samantha N Jensen, Nick Borcherding, Ashutosh K Mangalam
PDF DOI Pubmed
Single-cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes
Immune cells in the exposed conjunctiva mucosa defend against environmental and microbial stresses. Expression profiling by single-cell …
Jehan Alam, Ghasem Yazdanpanah, Rinki Ratnapriya, Nick Borcherding, Cintia S De Paiva, DeQuan Li, Stephen C Pflugfelder
PDF DOI Pubmed
IL-17 Producing Lymphocytes Cause Dry Eye and Corneal Disease With Aging in RXRα Mutant Mouse
Jehan Alam, Ghasem Yazdanpanah, Rinki Ratnapriya, Nick Borcherding, Cintia S De Paiva, DeQuan Li, Rodrigo Guimaraes de Souza, Zhiyuan Yu, Stephen C Pflugfelder
PDF DOI Pubmed
Dissecting the cellular landscape and transcriptome network in viral myocarditis by single-cell RNA sequencing
Coxsackievirus B3 (CVB3)-induced myocarditis is commonly employed to study viral pathogenesis in mice. Chronically affected mice may …
Ninaad Lasrado, Nick Borcherding, Rajkumar Arumugam, Timothy K Starr, Jay Reddy
PDF Code DOI Pubmed
Hypoglycemia secondary to insulinoma masking the onset of type 1 diabetes in an adolescent
Type 1 diabetes and insulinoma can co-occur in pediatric patients and may present with episodes of hypo- and hyperglycemia, significant …
Sriya Subramani, Andrew M Bellizzi, Nick Borcherding, Simon C Kao, Joseph Dillon, James Howe, Andrew W Norris, Michael J Tansey, Catherina T Pinnaro
PDF DOI Pubmed
Commentary on a Case of Unexpected Hyperglycemia
Nick Borcherding, Ann M. Gronowski
PDF DOI Pubmed
IL-12-induced immune suppressive deficit during CD8+ T-cell differentiation
Autoimmune diseases are characterized by regulatory deficit in both the CD4+ and CD8+ T-cell compartments. We have shown that CD8+ …
Pranav S Renavikar, Sushmita Sinha, Ashley A Brate, Nick Borcherding, Michael P Crawford, Scott M Steward-Tharp, Nitin J Karandikar
PDF DOI Pubmed
A transcriptomic map of murine and human alopecia areata
Alopecia areata (AA) is a common autoimmune condition, presenting initially with loss of hair without other overt skin changes. The …
Nick Borcherding, Sydney Crotts, Luana Ortolan, Nicholas Henderson, Nicholas Bormann, Ali Jabbari
PDF DOI Pubmed
A transcriptomic map of murine and human alopecia areata
An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPγ and heightened effector state in human CD8 T-cells
Multiple GWAS studies have shown that the SNP rs2281808 TT variant, present within the SIRPG gene, is associated with autoimmune …
Sushmita Sinha, Nick Borcherding, Pranav S Renavikar, Michael P Crawford, Eva Tsalikian,, Michael Tansey, Ezzatollah T Shivapour, Frank Bittner, John Kamholz, Heena Olalde, Emilee Gibson, Nitin J Karandikar
PDF DOI Pubmed
Calpain-5 expression in the retina localizes to photoreceptor synapses
Kellie A Schaefer, Marcus A Toral, Gabriel Velez, Allison J Cox, Sheila A Baker, Nick Borcherding, Diana F Colgan, Vimala Bondada, Charles B Mashburn, Chen-Guang Yu, James W Geddes, Stephen H Tsang, Alexander G Bassuk, Vinit B Mahajan
PDF DOI Pubmed