Paracrine WNT5A signaling in healthy and neoplastic mammary tissue


Paracrine signaling between mammary epithelial cells has long been appreciated. Recently, we found that Wnt5a, a novel noncanonical Wnt ligand of luminal origin, counteracts canonical Wnt signaling in basal mammary epithelial cells through a paracrine pathway, inhibits the expansion of Erbb2-induced tumor-initiating cells, and suppresses tumor incidence and metastasis.

In Molecular Cell Oncology
Nick Borcherding
Nick Borcherding
Assistant Professor

My research includes systems immunology, single-cell sequencing technology, and computational frameworks.