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scRepertoire 2: Enhanced and efficient toolkit for single-cell immune profiling
Single-cell adaptive immune receptor repertoire sequencing (scAIRR-seq) and single-cell RNA sequencing (scRNA-seq) provide a …
Qile Yang, Ksenia R. Safina, Kieu Diem Quynh Nguyen, Zewen Kelvin Tuong, Nick Borcherding
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scRepertoire 2: Enhanced and efficient toolkit for single-cell immune profiling
dandelionR: Single-cell immune repertoire trajectory analysis in R
Integration of single-cell RNA-sequencing (scRNA-seq) and adaptive immune receptor (AIR) sequencing (scVDJ-seq) is extremely powerful …
Jiawei Yu, Xiaohan Xu, Nick Borcherding, Zewen Kelvin Tuong
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Myelin-reactive CD8+ T cells influence conventional dendritic cell subsets towards a mature and regulatory phenotype in experimental autoimmune encephalomyelitis
Multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system, is modeled in mice as experimental …
Mohit Upadhye, Connor R. Wilhelm, Kai J. Rogers, Chakrapani Vemulawada,, Nick Borcherding, Alexander W. Boyden,, Kevin L. Legge, Nitin J. Karandikar
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TIFAB modulates metabolic pathways in KMT2A::MLLT3−induced AML through HNF4A
Tumor necrosis factor (TNF) receptor–associated factor (TRAF)–interacting protein with forkhead-associated domain B (TIFAB), an …
Yang Wang, Yan Xiu, Qianze Dong, Jinming Zhao, Kelao Neumbo, Masaru Miyagi, Nick Borcherding, Lin Fu, Havana De Celis, Nicolas Pintozzi, Daniel T. Starczynowski, Chen Zhao
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Leveraging single-cell transcriptomic data to uncover immune suppressive cancer cell subsets in triple-negative canine breast cancers
Single-cell RNA sequencing (scRNA-seq) has become an essential tool for uncovering the complexities of various physiological and …
Myung-Chul Kim, Myung-Chul Kim, Nick Borcherding, Woo-Jin Song,, Ryan Kolb, Weizhou Zhang
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CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia
The interplay between T-cell states of differentiation, dysfunction, and treatment response in acute myeloid leukemia (AML) remains …
Francesco Mazziotta, Luca Biavati, Joseph Rimando, Sergio Rutella, Nick Borcherding, Sonali Parbhoo, Rupkatha Mukhopadhyay, Sayan Chowdhury, Hanna A. Knaus, Peter Valent, Hubert Hackl, Ivan M. Borrello, Bruce R. Blazar, Katerina Hatzi, Ivana Gojo, Leo Luznik
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Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome
Mitochondria transfer is a recently described phenomenon in which donor cells deliver mitochondria to acceptor cells. One possible …
Ritsuko Nakai, Stella Varnum, Rachael L Field, Henyun Shi, Rocky Giwa, Wentong Jia, Samantha J Krysa, Eva F Cohen, Nick Borcherding, Russell P Saneto, Rick C Tsai, Masashi Suganuma, Hisashi Ohta, Takafumi Yokota, Jonathan R Brestoff
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CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mRNA vaccination induce robust CD4+ T cell responses. Using …
Nick Borcherding, Wooseob Kim, Michael Quinn, Fangjie Han, Julian Q Zhou, Alexandria J Sturtz, Aaron J Schmitz, Tingting Lei, Stefan A Schattgen, Michael K Klebert, Teresa Suessen, William D Middleton, Charles W Goss, Chang Liu, Jeremy Chase Crawford, Paul G Thomas, Sharlene A Teefey, Rachel M Presti, Jane A O'Halloran, Jackson S Turner, Ali H Ellebedy, Philip A Mudd
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CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph nodes and blood following mRNA vaccination in humans
Single-cell transcriptomics unveil profiles and interplay of immune subsets in rare autoimmune childhood Sjögren's disease
Childhood Sjögren’s disease represents critically unmet medical needs due to a complete lack of immunological and molecular …
Myung-Chul Kim, Umasankar De, Nick Borcherding, Lei Wang, Joon Paek, Indraneel Bhattacharyya, Qing Yu, Ryan Kolb, Theodore Drashansky, Akaluck Thatayatikom, Weizhou Zhang, Seunghee Cha
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Single-cell immune repertoire analysis
Single-cell T cell and B cell antigen receptor-sequencing data analysis can potentially perform in-depth assessments of adaptive immune …
Sergio Irac, Megan Sioe Fei Soon, Nick Borcherding, Zewen Kelvin Tuong
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